W-A-S-D keys could be used for something helpful.

While creating mockupts, I'm used to keeping my left hand at the home position. Mostly to keep the Shift,Ctrl, and Alt keys in constant use. So at least for me, it would be nice to use more keys in that position.

I was thinking of WASD like the arrow keys (like games do), and use them for align left|right|bottom|top. And Shift WASD could be used for something else. Both feel really comfortable while keeping my pinky near the left-control.