feedback from mic while in game picking up the game sounds

i have the zmx 122 professional mixer I use discord for gaming, when I am in game and on discord I am getting a HUGE amount of feedback for the others in the room how do i removed the feedback?
I have made sure that going in to sounds that all devices are disabled other than my head set that i am on which is headset only my speakers on my monitor are disabled.
Any help welcomed.
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