# General Strategy and Gameplay Discussion

## Conversations

Recent Conversations
Conversations 61 - 75 of 148
• 1 me too
• 0 replies
• Question
###### Multiloop boosting concept
Because i've never fully read the boosting guides, I experimented on boosting multiloops, and developed a concept, how to boost most mult...
• 1 me too
• 0 replies
• Article
###### A New Trick For Solving Puzzles: Catalyst Points
lroppy coined the term "boost points" a while ago (a red or green nucleotide put in a loop that lowers the energy of a loop), but since t...
• 13 me toos
• 7 replies
• Article
###### Reverse Engineering EteRNA's Energy Model
A few of us have been trying to understand the EteRNA Energy model so as to write better Puzzle Solver scripts and also learn how to des...
• 2 me toos
• 4 replies
• Article
###### G-U pairs often work the best if placed next to two A-U pairs
I have seen that when U bases alternate the best way to get a G-U pair in is to replace an A base with G base. When you have the stack AU...
• 1 me too
• 2 replies
• Article
###### Multi-player cooperative puzzle solving
Anyone think it would be productive and/or fun to copy the crowd sourced art motif and actually crowd source solve a single puzzle/lab? ...
• 1 me too
• 2 replies
• Article
###### Online chat with the EteRNA Team - switch puzzle strategies!
Now that we have been working on switch puzzles for a while, the EteRNA team wants to have a meeting with the players to discuss your str...
• 2 me toos
• 11 replies
• Article
###### Explanation Request: why does symmetry in internal loops have lower energy than similar, but smaller, sized asymmetric loops?
Is there a 3D or other explanation why the energy model for similar sized loops gives lower energy for a symmetric loop? For any (N+1) ...
• 3 me toos
• 3 replies
• Question
###### Explanation request: why do U-U mismatches provide a bonus in most internal loops?
Can anyone give a scientific explanation for why internal loops larger than 2-2 get U-U mismatch energy bonuses in the energy model we us...
• 2 me toos
• Question
###### Which way do I go?
As I progress through the "Challenges" I have been using the "next puzzle" link but I notice that some puzzles are omitted. In one case I...
• 1 me too
• Question
###### stuck on Broad's mod of Jet plane
I've solved all the other switch puzzles on page 23, but I can't figure out how to make the two side stacks in the primary (1) shape hold...
• 1 me too
• 5 replies
• Question
###### boosting multiple, consecutive, 1 nucleotide bulges
I see we have Guides to boost 1 nucleotide bulges, but I also think that these are pesky setups many puzzle designers use to confound th...
• 2 me toos
• 0 replies
• Question
###### WHAT DO I DO??? (I am such a newbie)
I know this sounds really well, dumb but I just started playing eteRNA and although I aced the tutorials I still don't get how to follow ...
• 1 me too
• 2 replies
• Question