G-quadruplexes

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http://en.wikipedia.org/wiki/G-quadru...

Just having a quick look over the recently published NUPACK designs. And I realised I had read about G quadruplexes before.
I'm not sure why, but the conditions that have been set for "NUPACK Design 4" for all the shapes involved, all have a quadruplex contained within.

Using the website http://bioinformatics.ramapo.edu/QGRS... to confirm.
Not sure if this has any relevance to the errors we are getting, but its very interesting to find this related.

Enjoy! :)
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Berex NZ

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Posted 9 years ago

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Jeehyung Lee, Alum

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This is interesting.

The synthesis team told us that the high rate of "G"s in NUPACK designs made them somewhat hard to analyze...perhaps this is related?