How important is Fold Change vrs Eterna Score?

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I have a question about Fold Change vrs Eterna Score in the labs. Is fold change more important for a successful switch than Eterna score or do you need to take both into account? I have some designs that scored high that I predicted would do poor but they do not have fold changes above 200. My other designs that were predicted to do good had fold changes up in the area of 400-500 and higher I think. So would the 200 and less fold change designs be considered poor performers and the 400-500 fold change designs be considered high performers? If so what is the triabl knowledge for the cutoff value for really good ver ehh designs.

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Jennifer Pearl

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Posted 2 years ago

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Eli Fisker

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Hi Jennifer!

As far as I understand, for the two hard labs, global fold change is what matters most. For the sublabs - especially the small ones with few inputs - fold change matters most.

Global fold change only reflects how well a certain puzzle is solving the main challenge - the two full OpenTB labs.

Global fold change ON follows the ABC2INC lab and Global fold change OFF follows the ABC2DEC lab.

And a fold change of 200 is pretty fine. 400-500 is really nice. You may want to look at the ddg numbers as these don't wary so wildly as fold change. Here is why it is worth a try.

And the more inputs there are, the lower the fold change tends to get.

Hope this helps.