A little long question: Why does the direction of the sequence matter?

I just found this and verified it as simple as possible in Hairpin Series:

You can build 2 solutions: (the order is from top to bottom if it's inline like at the start)

"cuuacaaaaagguggg" Total Energy: -1.8 Loopenergy:4

"ggguggaaaaacauuc" Total Energy: -2.5 Loopenergy:3

You can get from one to the other by a parity transformation (mirroring along the axis). Or if you just look at the sequence you have to reverse the order.

Now if RNA would be just a sequence of letters floating in space it shouldn't matter if i call one end of it first element and the other end last element or vice versa. So parity should be conserved/ the ordering shouldn't matter.

The only reason for this i can think of is if the real-world binding would be somehow directed. Is this the case ? And if not why does the ordering matter?

Also is there general rule how to use this effect ingame?

I just found this and verified it as simple as possible in Hairpin Series:

You can build 2 solutions: (the order is from top to bottom if it's inline like at the start)

"cuuacaaaaagguggg" Total Energy: -1.8 Loopenergy:4

"ggguggaaaaacauuc" Total Energy: -2.5 Loopenergy:3

You can get from one to the other by a parity transformation (mirroring along the axis). Or if you just look at the sequence you have to reverse the order.

Now if RNA would be just a sequence of letters floating in space it shouldn't matter if i call one end of it first element and the other end last element or vice versa. So parity should be conserved/ the ordering shouldn't matter.

The only reason for this i can think of is if the real-world binding would be somehow directed. Is this the case ? And if not why does the ordering matter?

Also is there general rule how to use this effect ingame?