Novice question re two global cache devices

I'm new to this and still contemplating buying irule builder and global cache hardware. My question is... My TV is some distance from my av cabinet. To power on the tv can I have a second global cache IR device so that part of my macro tells one GC to turn on the TV and the rest of the codes go to a second GC that handles the components in the cabinet? Can one macro manage two separate GC devices? Or do I put a long-run IR emitter back to the TV and work through only one GC in tehe cabinet? Or is there a better way entirely?
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